Table 2 In vivo Nanotechnology-based Scaffold in skin regeneration
From: Nano drug delivery systems: a promising approach to scar prevention and treatment
Nanomaterial | biomolecule or drug | Model | Major outcomes | Ref |
|---|---|---|---|---|
Nanofibrous scaffolds comprising polyvinyl pyrrolidone (PVP), cerium nitrate hexahydrate (Ce(NO3)3·6H2O) | Curcumin(Cur) | Rat full-thickness skin wound model | Scarless wound healing; reduced local oxidative stress | [55] |
Dextran based bionanocomposite membranes | Clove oil (CO) and sandalwood oil (SO) | Mouse full-thickness skin wound model | Scarless wound healing; proper collagen formation and organization, and presence of hair follicles | [56] |
Sulphonated polyether ether ketone (SPEEK) nanofibrous scaffold | Aloe vera | Rat excision skin wound model | Scarless wound healing; excellent pathogenic inhibition | [57] |
Amniotic membrane (AM)/SF membrane | Adipose tissue-derived mesenchymal stem cells | Mouse third degree burn wound model | Scarless wound healing; accelerated wound healing, neo-vascularization and early re-epithelialization | [58] |
Ag/Glass–ceramics (GC)-Ch/polyethylene oxide (PEO)/Gel electrospun scaffolds. | Mouse embryonic fibroblasts | Mouse full-thickness skin wound model | Scarless cutaneous wound regeneration; enhanced angiogenesis, and collagen synthesis as well as regeneration of the sebaceous glands and hair follicles | [59] |
Silver-catechin nanocomposite tethered collagen scaffolds | Silver-catechin nanocomposite | Rat full-thickness skin wound model | Scarless wound healing; increased angiogenesis | [60] |
ZnO–curcumin nanocomposite tethered collagen scaffolds | ZnO–curcumin nanocomposite | Rat burn wound healing model | Scarless wound healing; upregulates angiogenesis and TGF-β3 expression thereby | [61] |