Table 3 In vivo Nanotechnology-based gel in skin scarring

In situ gel composed of self-assembled lattice nanostructures

PFD

Mouse deep partial thickness (DPT) burn

Scar inhibition: accelerated healing process and shortened inflammation phase

[76]

Carboxymethyl chitosan (CMC)/aldehyde-modified CNC (DACNC) nanocomposite self-healing hydrogels

—

Rat deep partial thickness burn model

Prevent scarring; accelerated deep partial thickness burn wound healing

[77]

Nanoethosome Gels

ALA

Rabbit HS models

Improved HS; remodeling collagen fibers

[78]

Gelatin methacryloyl-dopamine(GelMA-DOPA) hydrogel

CONPs and an antimicrobial peptide (AMP)

Rat wound and infection model

Decreased scar formation; accelerated wound healing.

[79]

AgNPs gels

—

Methicillin-Resistant Staphylococcus pseudintermedius(MRSP) infected mice wound model

Reduced scar appearance; improved collagen fiber alignment and reduced pus formation

[80]

Fe-SiO2 nano composites membrane and hydrogel

Curcumin

Mouse full-thickness skin wound model

Inhibiting scar hyperplasia; promoting hair follicle regeneration.

[81]

Nanoethosomes gel

IR-808

Rabbit ear HS model

Remarkable therapeutic effects on improving the

HS appearance, promoting HSF apoptosis and remodeling collagen fibers

[82]

Self-assembled peptide-hydrogels

Resveratrol

Rat full-thickness skin wound model

Scar inhibition; Accelerated wound healing, well-organized collagen deposition, reduced inflammation

[83]

Composite hydrogel is composed of modified polycaprolactone nanofiber with plasma treatment

—

Mouse full-thickness skin wound model

No obvious scar; promotion of skin wound healing

[84]