Table 4 In vivo Nanotechnology-based gel in skin regeneration
From: Nano drug delivery systems: a promising approach to scar prevention and treatment
Nanomaterial | biomolecule or drug | Model | Major outcomes | Ref |
|---|---|---|---|---|
Sodium alginate gum acacia polymeric nanocomposite hydrogels | Zinc oxide nanoparticles (ZnO NPs) | Rabbit full-thickness excision model | Scarless wound healing; reduced inflammation, accelerated healing, | [85] |
Intercalated N-CNS polymer nanocomposites (ICPN) and HCPN (heptazine N-CNS polymer nanocomposites) | Losartan | Rat deep second-degree wound model | Excellent scarless healing | [86] |
(PAGE)-based nanogel | CONPs and curcumin | Rat full-thickness skin wound model | Scarless healing; early resolution of inflammation and regrowth of hair follicles | [87] |
MXene nanofibers @ VEGF core with dopamine-hyaluronic acid hydrogel@dopamine shell(MNFs@V–H@DA) | VEGF | Mouse wound-healing model | Scarless healing; appropriate vascularization, anti-inflammatory effects | [88] |
AgNPs/Glucose oxidase nanocapsules (nGOx)/apramycin (Apra) nanocomposite gel | Glucose oxidase (GOx) | Rabbit coli-induced inflammation model and mice Propionibacterium acnes-induced inflammation model | Rapid scarless skin recovery; significant bacterial growth inhibition and broad antimicrobial spectra | [89] |
Silk nanofiber hydrogels | Bone marrow mesenchymal stem cells (BMSCs) | Rat full-thickness skin wound model | Scarless healing with hair follicle recovery | [90] |
silk nanofiber hydrogels | Asiaticoside(AC) | Rat full-thickness skin wound model | Scarless wound repair; regulated inflammatory reactions and angiogenesis | [91] |