Table 5 In vivo nanoparticles in skin scarring
From: Nano drug delivery systems: a promising approach to scar prevention and treatment
Nanomaterial | biomolecule or drug | Model | Major outcomes | Ref |
|---|---|---|---|---|
CONPs | — | Rabbit ear scar model | Improved the scar appearance and collagen arrangement | [3] |
Liposome | Statins | Rabbit ear models of HS | Significantly reduced hypertrophic scarring; reduced erythema/vascularity of scars | [97] |
DNA-Fe nanoparticles | Doxorubicin hydrochloride (DOX) | Rabbit HS models | Scar-inhibiting effects; penetration ability, rapid drug release | [98] |
Light-controlled thermosensitive Nanoformulation(TSLC) | Cell membrane repair protein (rhMG53) | Rat diabetic model with full-thickness cutaneous wounds | Reduction in scar formation; inhibited excessive skin fibrosis, angiogenesis, and increased wound closure rate | [99] |
Papain elastic liposomes (PEL) | Papain elastic | Rabbit ear model | Improved HS; significantly decreased microvascular density, and collagen fiber | [100] |
Selenium@SiO2 nanoparticles (Se@SiO2NPs) | — | Rat full-thickness skin wound model | Suppressed the formation of hypertrophic scars and accelerated dermal wound healing, accompanied by oxidative stress inhibition | [101] |