Fig. 7

W-Exo-L@GelMA exhibits a therapeutic effect on human OA cartilage explants by promoting aggrecan and suppressing MMP13 expression. A Schematic diagram of the procedures of the human OA cartilage explant harvest and treatments. The human OA cartilage explants were harvested from the medial condyle of the femur of the OA patients undergoing total knee arthroplasty. B Representative image of the harvested human OA cartilage explant. C Representative images of Immunohistochemistry analyses of the aggrecan and MMP13 expression levels in the IL-1β- maintained explants treated with or without W-Exo-L@GelMA (5.0 µM) for 72 h. Scar bar: 200 μm. D Quantitative analyses of immunohistochemistry. Data represent mean ± SD; N = 3/group. *P < 0.05 by paired t-test