Table 1 ROS scavenging and modulating strategy
Cell model | Nanoparticles | Drug loading | ROS scavenging and modulating | Targeting strategies | Results | Refs. |
|---|---|---|---|---|---|---|
Raw 264.7 | CD9-HMSN@RSV | RSV | ROS generation inhibition | Active targeting (CD9) | Anti-aging, anti-inflammatory, targets macrophages | [56] |
Raw 264.7 | CFNs | \ | Clear O2·−, ·OH | Active targeting (P-Selectin) | Anti-inflammatory, antioxidant, targeted plaques | [57] |
Raw 264.7 | IL10-cRGD-Lip | IL10 | ROS generation inhibition | Active targeting (cRGD) | Anti-inflammatory, nitric oxide inhibition | [58] |
Raw 264.7 HUVECs | PCZ@PB NCs | PB | Clear H2O2, O2·− | Passive targeting | Anti-inflammatory, antioxidant, and drug delivery | [59] |
Raw 264.7 HUVECs VSMCs | HA-M@PB@ (PC + ART) | ART, PC | ROS generation inhibition | Passive targeting | Anti-inflammatory, lipid modulation, enhanced autophagy, antioxidant | [60] |
Raw 264.7 | Gd/CeO2 Nanozyme | \ | Clear H2O2, O2·− | Passive targeting | Inhibition of foam cell formation, macrophage migration, broad spectrum ROS scavenging | [61] |
Raw 264.7 | Cur-MnO2/HA | Cur | Clear H2O2, O2·−, ·OH | Passive targeting | Inhibition of HIF-1α expression promotes macrophage polarization to M2 type | [62] |
J774A.1 CHO | CeO2-Fe3O4@LDH | \ | Clear H2O2 | Passive targeting | The antioxidant, potential contrast agent | [55] |
Raw 264.7 VSMCs | TPCD NPs | \ | Clear H2O2, O2·−, ClO− | Passive targeting | Broad spectrum ROS scavenging, stabilized plaque | [63] |
Raw 264.7 | ATOR-loaded PLGA/miRNA | ATO | ROS generation inhibition | Passive targeting | Anti-inflammatory and promotes macrophage polarization to M2 type | [64] |
Raw 264.7 | TN-PdH | \ | Clear H2O2, O2·−, ·OH | Passive targeting | Anti-inflammatory, antioxidant, induction of autophagy in macrophages | [65] |