Table 2 ROS responsive Strategy
Cell model | Nanoparticles | Drug loading | ROS response method | Targeting strategies | Results | Refs. |
|---|---|---|---|---|---|---|
RAW 264.7 | HASF@Cur | Cur | Material (Thioketal linkages and Ferrocene) has ROS responsiveness | Active targeting(CD44) | Lysosomal escape and reduction in plaque area | [88] |
RAW 264.7 | TPCDP@PMM | Pred | Material (Polymer blocks) has ROS responsiveness | Active targeting(VCAM-1, CD44) | Anti-inflammatory, hypolipidemic, diagnostic | [89] |
RAW264.7 HUVECs | MM-AT-NPs | \ | Material (Chitosan oligosaccharide)has ROS responsiveness | Passive targeting | Anti-inflammatory, immune escape | [48] |
RAW264.7 HUVECs | MM/RNPs | RAP | Material (Boronic esters) has ROS responsiveness | Passive targeting | Immune escape, inhibition of macrophage, and smooth muscle cell proliferation | [90] |
RAW 264.7 MAECs | HA-Fc/NP3ST | \ | Material (Ferrocene) has ROS responsiveness ROS | Passive targeting | Anti-inflammatory, greater plaque penetration, and reduced plaque size | [91] |