Table 3 ROS responsive and ROS scavenging strategies

RAW 264.7

HUVECs

LFP/PCDPD

Pred

Clear ROS

Active targeting (VCAM-1, CD44)

Anti-inflammatory, lipid removal, fluorescent imaging

[102]

RAW 264.7

PLCDP@PMH

Pred

Clear ROS

Active targeting (VCAM-1, CD44)

Lipid modulation, inhibition of macrophage polarization to M1 type, plaque diagnosis

[103]

RAW 264.7

LO2

HA/HPEMs

SIM

Clear ROS

Active targeting

(CD44)

Anti-inflammatory, antioxidant, inhibits macrophage growth

[104]

RAW 264.7

RBC/LFP@PMMP

Pred

Clear ROS

Passive targeting

Anti-inflammatory, antioxidant, and lipid imaging

[105]

RAW 264.7

HUVECs

SV MC@RBCs

SIM

Clear ROS

Passive targeting

Anti-inflammatory, antioxidant, antithrombotic, shear stress responsive

[106]

RAW 264.7

ECs

RP-PU

PB

Clear ROS

Passive targeting

Anti-inflammatory, antioxidant, hypolipidemic, inhibits foam cell formation

[107]

RAW 264.7

HUVECs

KPF@MM-NPs

KPF

Clear ROS

Passive targeting

Anti-inflammatory, antioxidant, promotes macrophage polarization from M2 to M1 type and enhances internalization

[108]

RAW 264.7

HUVECs

SA PAM@RBCs

SIM

Clear ROS

Passive targeting

Antioxidant reduces plaque count, shear stress responsive

[109]

RAW 264.7

TPP@PMM

Pred

Clear ROS

Passive targeting

Anti-inflammatory, antioxidant, inflammatory diagnosis

[110]

RAW 264.7

LO2

TPTS/C/T

SIM

Clear ROS

Passive targeting

Anti-inflammatory, antioxidant, inhibits macrophage polarization to M1 type, synergistic therapy

[111]

RAW 264.7

HUVECs

SE-LNPs

SIM

Clear ROS

Passive targeting

Anti-inflammatory, antioxidant, anti-apoptotic, hypolipidemic, promotes macrophage polarization to M2 type

[112]

RAW 264.7

PEG-PPS

Andro

Clear ROS

Passive targeting

Anti-inflammatory, antioxidant

[113]