Fig. 10

Biosafety evaluation in vivo. A Histological assessment of heart, liver, spleen, lung and kidney tissues of mice after treatment. The scale bar is 100 µm. B–D Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total protein (TP), albumin (ALB), globulin (GLB), creatinine (CREA), urea and uric acid (UA) levels from the mice treated with PBS and HACB NPs (1.5 mg/kg, i. v.) for 24 h. Data are shown as mean ± S. D. (n = 5)