Fig. 9
In vivo tumor therapeutic effect of HACB/BCNU NPs. A Tumor growth curves and B average tumor weight of the mice after injection with saline, BCNU, BCNU + O6-BG and HACB/BCNU NPs. C Image of tumors harvested after 15 days post-treatment. D Image of tumor-bearing mice after treatments. E The body weight variation of HeLa tumor-bearing mice during treatment. F Histological observation and detection of apoptosis in tumor tissues after treatment. The red circles indicate sites of apoptosis. Data are shown as mean ± S. D. (n = 5), *p < 0.05, **p < 0.01 and ***p < 0.001