Fig. 2
From: Application of biomedical materials in the diagnosis and treatment of myocardial infarction
DSPE-PEG encapsulated hydrophobic iron oxide nanocubes for targeted MRI detection. (A) Schematic illustration of improving the colloidal stability and biocompatibility of hydrophobic nanocubes using DSPE-PEG. (B) Prussian blue staining of RAW264.7 cells cultured without (I) or with (II) MFRN. Cells were stained in red and MFRN in the cytoplasm was stained in blue. (C) In vivo 7 Tesla cardiac MR images before and 24Â h after intravenous injection of MFRN, and with or without external magnetic exposure measures. White arrows point to infarcted tissue. (D) Negative contrast is stronger with injection of MFRN and with magnetic exposure. Reproduced with permission [135]. Copyright 2016, Wiley-VCH