Fig. 5
Copyright 2022, American Chemical Society
Schematic diagram of siRNA-loaded EVs conjugated with c(RGDyK) and their anticancer effects. A A diagram illustrating a two-step reaction that involves conjugating c(RGDyK) and Cy5.5 fluorophore or cholesterol-modified siPDL1 to the amine group of EVs. B Quantification of tumor-associated fluorescence radiance intensity with data presented as the mean ± SEM; **P < 0.01, ***P < 0.001, ****P < 0.0001, by one-way ANOVA. C Kaplan–Meier survival curves are shown (n = 10) [91]. Reprinted with permission.