Fig. 3

Biodistribution of FeDOX@cellMBs in orthotopic GBM mice. (A) Distributions of FeDOX@MBs and FeDOX@cellMBs visualized by IVIS Lumina II in vivo optical imaging. (B) The fluorescence intensity of FeDOX@MBs and FeDOX@cellMBs to brain in orthotopic GBM mice. (C) Fluorescence in intact organs in orthotopic GBM mice 12 and 24 h after intravenous injection of FeDOX@MBs and FeDOX@cellMBs. (D) Semi-quantitative statistic results of fluorescence intensity in main organs collected 12 h after injection of FeDOX@MBs and FeDOX@cellMBs. (E) Semi-quantitative statistic results of fluorescence intensity in main organs collected 24 h after injection of FeDOX@MBs and FeDOX@cellMBs. (F) Distribution of FeDOX@MBs and FeDOX@cellMBs in GBM tissue of orthotopic GBM mice observed by CLSM. (n = 3, x ± SD. * P < 0.05, ** P < 0.01)