Fig. 7

Overexpression of circ_0001785 leads to reduced endothelial injury and enhanced left ventricular diastolic function in mice A Mice were divided into 5 groups. ApoE^−/− mice were injected with circRNA in the tail vein. B Echocardiographic testing to analyze cardiac function after the onset of AMI in each group (left). C HE-stained images of atherosclerotic lesions and aortic root lesion areas. D Immunohistochemical staining of endothelial CD31 at the aortic root lesion in mice. E Percentage of left ventricular ejection fraction (EF). F Percentage of short-axis shortening (FS) of the left ventricle. G Area of HE staining of aortic root lesions. H qRT-PCR detection of circ_0001785 expression in control and ApoE.^−/− + AMI mice. Results are expressed as mean ± SEM; Student's t-test or one-way ANOVA. *P < 0.05