Fig. 8

Flow chart. In this experiment, we demonstrated that the plasma exosome circ_0001785 functions as a ceRNA to regulate the downstream expression of TGFBR3 by "sponging" miR-513a-5p. Through this pathway, circ_0001785 promoted the proliferation and cell viability of ECs, and inhibited the apoptosis and migration of ECs, resulting in a reduction of plaque size and improved cardiac function in mice with AS, thus affecting the development and progression of AS