Fig. 3

Temperature variation curve and pH-sensitive Dox release of B7H3/Dox@GNCs. A Temperature increasing curve of B7H3/DOX@GNCs under different solution concentrations. B Temperature increasing curve of B7H3/DOX@GNCs under with different NIR irradiation intensity. C Photothermal stability of B7H3/DOX@GNCs with four cycles of laser on/off. D The release curve of DOX from B7H3/DOX@GNCs at pH 7.4, 6.5, and 5.5. Data are Mean ± SD (n = 3), ^*P < 0.05 and ^**P < 0.01, (one-sample t-test) versus pH 5.5 group. E, F) flow cytometry quantification of B7H3 variants on NCI-H1299 cells (Top picture is the isotype control group, bottom picture is the experimental group)