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Table 1 Pharmacokinetic parameters of Dox•HCl, Dox@GNCs, and B7H3/Dox@GNCs after single intravenous administration in rats (Mean ± SD, n = 6)

From: B7H3 targeting gold nanocage pH-sensitive conjugates for precise and synergistic chemo-photothermal therapy against NSCLC

PK Parameters

Dox•HCl

Dox@GNCs

B7H3/Dox@GNCs

T1/2 (h)

8.67 ± 0.34

14.72 ± 1.36**

21.32 ± 2.46**

AUC0-∞ (h·mg/mL)

36.49 ± 1.27

245.48 ± 17.92**

568.45 ± 36.54**

Vd (L/kg)

1.64 ± 0.41

1.15 ± 0.63**

0.87 ± 0.56**

CL (L/h/kg)

0.13 ± 0.00

0.08 ± 0.00**

0.05 ± 0.00**

MRT0-∞(h)

9.43 ± 0.46

15.97 ± 1.54**

23.48 ± 2.06**

  1. *P < 0.05, **P < 0.01 versus Dox•HCl group (one-sample t-test)
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Journal of Nanobiotechnology

ISSN: 1477-3155

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