Fig. 3

(a) In vivo fluorescence imaging of HCT116 tumor-bearing mice at 0, 1, 6, 12, 24 and 48 h after intravenous administration of TPSe NPs. (b) Fluorescence intensity from (a) plotted as a function of time post-injection. (c) Fluorescence image and (d) fluorescence intensity of tumor and other major organs, including heart, liver, spleen, lung, kidneys and intestine after 24 h post-injection of TPSe NPs. (e) Thermal image of the mice in PBS + Laser (L) group and TPSe NPs (0.5 mg mL^− 1 or 1.0 mg mL^− 1) + L group upon irradiation and (h) temperature profiles of tumor regions upon irradiation using 808 nm laser. (f) Representative photograph of mice and (g) tumors in different groups after 12 days treatment. (i) Tumor volume changes of mice between 12 days. (j) Weight of mice in different groups between 12 days. (k) Tumor weight of mice at 12 days