Fig. 3
(Reproduced under the terms of the CC-BY 4.0. Copyright 2022, The Authors, published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles)
Targeted delivery of circDYM to brain by genetically engineered EVs with RVG peptide for CUS treatment [112]. A Schematic diagram of the production of RVG-decorated and circDYM-packaged EVs from HEK 293T cell. B Representative near infrared fluorescence (NIRF) images of mice brains after intravenous administration of DiR-labelled mock EVs or RVG-EVs (200 μg) at different time points. C The significantly relieved depressive-like behaviors by RVG-EVs delivered CircDYM in CUS mice as measured by the behavior tests, including SPT, FST, TST and OFT (n = 6 for each group) (*P, **P, ***P vs the Control + RVG-Vector-EVs group; #P, ##P, ###P vs the CUS + RVG-Vector-EVs group). *P, #P < 0.05; **P, ##P < 0.01; ***P, ###P < 0.001. Two-way ANOVA followed by the Holm–Sidak test were used for the multiple comparisons