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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: Targeted therapy using engineered extracellular vesicles: principles and strategies for membrane modification

Fig. 7

Proposed model of chemical biology approaches for surface engineering of EVs. A The exosomal membrane proteins fused with HaloTag, SNAP-tag, CLIP-tag, ybbR tag, SpyTag, and SnoopTag are expressed in eukaryotic cells. The specific ligands for each tag consisting of ligands conjugated with targeting moieties can be covalently immobilized on the exosome membrane with surface chemical reaction. B Incorporating non-canonical amino acids into EV membrane proteins can promote the azide-alkyne cycloaddition. Then an alkynyl-bearing protein is conjugated to an azide-labeled targeting moiety such as peptide/protein/antibody/nanobody etc.

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Journal of Nanobiotechnology

ISSN: 1477-3155

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