Fig. 9

Histological analysis of skin biopsies. H & E staining revealed the existence of significant inflammatory cells and exudate (black arrows) in the mat-free rats compared to the other groups (A). The application of electrospun PC, PCS, PCS/TMP/TMPNPs can reduce the excessive inflammatory response, exudate, and fibrotic changes. These properties were more prominent in the PCS/TMP/TMPNPs group. Unlike PC and PCS groups, placing PCS/TMP/TMPNPs mats at the site of injury can lead to the restoration of epidermis structure after three weeks. Monitoring the Desmoglein protein levels in different groups using IF images (B. Magnification 20X). Data showed that PCS/TMP/TMPNPs efficiently promote the synthesis of Desmoglein compared to other experimental groups, resulting in appropriate cell-to-cell connection