Fig. 1From: Nano-immunotherapy: overcoming delivery challenge of immune checkpoint therapyRepresentative profile of potential ICPs with relevant specific ligands and their function on CD8/CD4+ T cells. The interaction among negative co-inhibitory ICPs on CD8/CD4+ T cells, including TIM-3, PD-1, LAG-3, CTLA-4, VISTA, TIGIT, and BTLA-4 and positive co-inhibitory ICPs interact with TCR, and CD28 with their membrane protein of APC or tumor cellsBack to article page