Fig. 4

a Schematic illustration of traumatic SCI repair based on NIR-triggered NO release. b Morphological changes of UCZNs-treated dorsal root ganglion (DRG) neurons upon 980 nm light stimulation. The red arrows mark the damage region caused by highly treating power density of NIR (Scale bar, 25 μm). Reprinted with permission [38]. Copyright 2020, AAAS. c Schematic diagram showing the molecular structure, light-induced isomerization and the gate effect on ORAI1 channel of piCRAC-1. d Representative whole-cell currents (left) and I-V relationships of three time points (right) of ORAI1-SS-GFP-expressing HEK293 cells in DVF solution having piCRAC-1. e Representative areas of HEK293 cells performing piCRAC-1-induced local modulation on store-operated calcium entry (SOCE). f Lateral images showing Tg (CD41: EGFP) embryos which express R304W activating mutant or STIM1 in wild type (WT) with or without piCRAC-1. Reprinted with permission [58]. Copyright 2020, ACS