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Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: Dominoes with interlocking consequences triggered by zinc: involvement of microelement-stimulated MSC-derived exosomes in senile osteogenesis and osteoclast dialogue

Fig. 1

Like a domino, senile osteoporosis patients increase the expression of trace elements by engineering the microenvironment in which the mesenchymal stem cells are located. The altered exosome content secreted by engineered aging BMSCs directly affects the downstream BMSC-BMMs intercellular communication, and the transient increase in osteoclasts is abolished. Finally, the local osteogenic differentiation ability of senile osteoporosis was improved, and miRNA146b-5p was verified as a key regulator, its downstream signaling AKT/M-Tor pathway was detected

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Journal of Nanobiotechnology

ISSN: 1477-3155

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