Fig. 2
MSCsSC-Exos treatment repairs the damaged articular cartilage in OA rat model. A Representative image of DiO-labelled MSCsSC-Exos were uptaken by the damaged cartilage. White dotted lines indicate articular surface and the green dots indicate DiO-labelled MSCsSC-Exos. Scale bar: 100 μm. B Schematic diagram of MSCsSC-Exos treatment strategy in OA rats. C Safranin O/fast green staining of cartilage morphology in each group rats, scale bar: 500 μm (up) and 100 μm (down). D The OARSI scoring system quantify the severity of cartilage destruction. n = 6 for each group. E and F The immunofluorescence analysis of COL2A1 and MMP-13 in articular cartilage of OA rat model. n = 6 for each group. Scale bar: 100 μm. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.001, ns not significant