Fig. 6
Antagomir-199a-3p abrogates MSCsSC-Exos therapeutic effect on damaged cartilage in OA model. A Schematic diagram of antagomiR-199a-3p and MSCsSC-Exos treatment strategy in OA rats. B Safranin O/fast green staining of cartilage morphology in each group rats, scale bar: 500 μm (up) and 100 μm (down). C The OARSI scoring system quantify the severity of cartilage destruction. n = 6 for each group. D and E The immunofluorescence analysis of COL2A1 and MMP-13 in articular cartilage in OA rat model. n = 6 for each group. Scale bar: 100 μm. F and G The immunofluorescence analysis of mTOR and LC3B in articular cartilage in OA rat model. n = 6 for each group. Scale bar: 100 μm. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.001, ns not significant