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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: Exosomes derived from LPS-preconditioned bone marrow-derived MSC modulate macrophage plasticity to promote allograft survival via the NF-κB/NLRP3 signaling pathway

Fig. 7

The expression of MiRNA-222-3p in LPS pre-Exos was sharply increased and it can regulate macrophages through exosomal transfer. A The heatmap showed the differential expression of miRNAs between Bm-Exo group and LPS pre-Exo group (n = 3). (Fold change > 1.0; P < 0.05). B The volcano plot demonstrated the altered expression levels of miRNAs between Bm-Exos and LPS pre-Exos. C The KEGG analysis of target genes associated with differentially expressed miRNAs showed that 30 signaling pathways were significant enriched (P < 0.05). D Gene Ontology (GO) analysis was conducted on the target genes of differentially expressed miRNAs (P < 0.05). E The qPCR analysis demonstrated the differential expression level of miR-486, miR-206-3p, miR-409a-3p, miR-543-3p, miR-144, miR-222-3p, miR-1b, and miR-411-3p in Bm-Exo group and LPS pre-Exo group. Data are presented as mean ± SD (n = 3). *** P < 0.0005

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Journal of Nanobiotechnology

ISSN: 1477-3155

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