Fig. 4
From: Customizing cancer treatment at the nanoscale: a focus on anaplastic thyroid cancer therapy
LPm NP exhibited favorable performance in delivering NIS mRNA and 131I, demonstrating promising adjunctive therapy for patients with ATC by restoring iodine affinity and enhancing the therapeutic efficacy of radioactive iodine. A Schematic diagram of the structure of LPm NPs and their function of transporting NIS mRNA in cells for protein expression. B SPECT/CT imaging of mice treated with saline, NIS-mRNA LPm NPs, 131I, EGFP‐mRNA LPm NPs + 131I, or NIS‐mRNA LPm NPs + 131I for 24 h. C Image of the excised subcutaneous tumor on day 18. Figure adapted from Qinglin Li et al. [67]