Fig. 8

The targeting performance of NDF-M1/H gel microspheres. A and B In vivo and ex vivo images of NDF-M1/H gel microspheres with Cy5.5 dye in the colorectum. The acute colitis mice model was established by oral administration of 3% DSS for 7 days. Mice with acute colitis were administered an oral gavage of NDF-M1/H gel microspheres with Cy5.5 dye following a 24 h fast. In vivo and ex vivo fluorescence images were obtained by IVIS Spectrum after 24 h treatment (n = 3). C Immune staining of IL-1β distributed in the colorectum (red arrows) from the specific region (green boxes). D Representative H&E-stained histological sections of colonic tissues from the specific region (green boxes). The degree of inflammatory cell infiltration is delineated (green arrows)