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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Hypoxic mesenchymal stem cell-derived exosomes promote the survival of skin flaps after ischaemia–reperfusion injury via mTOR/ULK1/FUNDC1 pathways

Fig. 6

High-throughput sequencing analysis of miRNAs in Hypo-Exo and Exo. A Clustered heat map of differentially expressed miRNAs depicting up and down regulated miRNAs. B, C GO and KEGG enrichment of differentially expressed miRNAs. D Volcano plot of differentially expressed miRNAs depicting up and down regulated miRNAs. E Autophagosomes and autolysosomes in each group (bar size 10 μm). F Quantitative analysis of autophagosomes and autolysosomes in each group (****P < 0.0001). G, H Western blot shows the expression of FUNDC1, LC3-I, LC3-II in flap treated with each group, and quantitative data of western blot analysis (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001), Bars indicated means ± SD

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