Fig. 6

LP-S efficiently targeted metastatic LNs in vivo. (a) Schematic of LN tumor metastasis detection after local injection of LP-S. (b) Representative NIR fluorescence images and heat maps of popliteal tumor metastatic lymph nodes (T-LNs, red circle) and contralateral normal lymph nodes (N-LNs, yellow circle) at different time points after local injection of LP-S (25ug/ml, 50ul). (c) Fluorescence images of excised T-LNs and N-LNs after 24 h of injection (n = 3 mice/group). (d) Quantitative analysis of fluorescence intensity in T-LNs and N-LNs shown in (b) (mean ± SD, n = 3). (e) Signal to background ratio (SBR) of T-LNs and N-LNs shown in (b) (mean ± SD, n = 3)