Fig. 10

In vivo anti-TB effects of Rif@IONPs-PAA-PEG-MAN nanodecoy-assisted anti-TB strategy in Mtb infected mice. A IVIS imaging for in vivo distribution of GFP-BCG and DI@IONPs-PAA-PEG-MAN in mice at different time points after intravenous injection. B IVIS imaging for the distribution of GFP-BCG and DI@IONPs-PAA-PEG-MAN in different organs of mice after 72 h of intravenous injection (sacrificed), He means heart, Lv means liver, Sp means spleen, Lu means lung and Kd means kidney. C Diagram for the exprimental design of Mtb infected mice model and drug administration for the Mtb infected mice, normal group means mice without Mtb infection and drug treatment, control group means mice with Mtb infection and with saline treatment. D Body weight of mice in different groups at the endpoint of the experiment, n = 8. E Spleen weight of mice in different groups at the endpoint of the experiment, n = 8, ANOVA-Tukey analysis was applied for the comparative analysis of data, *p < 0.05, ***p < 0.001. F Bacterial loads in the lung of mice from Mtb infected mice at the endpoint of the experiment, n = 8, ANOVA-Tukey analysis was applied for the comparative analysis of data, ***p < 0.001. G Typical 7H11 plates coated with the lysis of lungs for CFU counting of Mtb in the lungs at the endpoint of the experiment. H Typical images of the H&E stained lung tissues of mice from different groups, green arrows indicated the inflammatory infiltrates and hemorrhages structures and blue arrows indicated the red cells