Fig. 11

Organ tissue structures and serum hepatic/renal function evaluations of mice, normal groups means mice without Mtb infection and drug treatment, control group means mice with Mtb infection and with saline treatment. A Typical images of the H&E stained heart tissues of mice from different groups. B Typical images of the H&E stained liver tissues of mice from different groups. C Typical images of the H&E stained spleen tissues of mice from different groups. D Typical images of the H&E stained kidney tissues of mice from different groups. E Serum ALT concentrations in mice from different groups, n = 8, *p < 0.05, ANOVA-Tukey analysis was applied for the comparative analysis of data, ***p < 0.001. F Serum AST concentrations in mice from different groups, n = 8. G Serum BUN concentrations in mice from different groups, n = 8, ANOVA-Tukey analysis was applied for the comparative analysis of data, *p < 0.05. H Serum CRE concentrations in mice from different groups, n = 8