Fig. 8

Enhanced killing efficiency of Rif@IONPs-PAA-PEG-MAN on intracellular M.tb in infected macrophages. A Effects of IONPs-PAA-PEG-MAN, rifampicin and Rif@IONPs-PAA-PEG-MAN on the growth of extracellular BCG, control group means extracellular BCG without drug treatment, n = 3, ANOVA-Tukey analysis was applied for the comparative analysis of data, ***p < 0.001. B Effects of IONPs-PAA-PEG-MAN, rifampicin and Rif@ IONPs-PAA-PEG-MAN on the growth of intracellular BCG in infected THP-1 cells, control group means BCG-infected THP-1 macrophages without drug treatment, n = 3, ANOVA-Tukey analysis was applied for the comparative analysis of data, ***p < 0.001. C Typical images of 7H11 plates for intracellular BCG in infected THP-1 cells, control group means BCG- infected THP-1 macrophages without drug treatment. D Effects of IONPs-PAA- PEG-MAN, rifampicin and Rif@IONPs-PAA-PEG-MAN on the growth of extracellular H37Rv, control group means extracellular H37Rv without drug treatment, n = 3, ANOVA-Tukey analysis was applied for the comparative analysis of data, ***p < 0.001. E Effects of IONPs-PAA-PEG-MAN, rifampicin and Rif@IONPs-PAA-PEG-MAN on the growth of intracellular H37Rv in infected THP-1 cells, control group means H37Rv-infected THP-1 macrophages without drug treatment, n = 3, ANOVA-Tukey analysis was applied for the comparative analysis of data, ***p < 0.001. F Typical images of 7H11 plates for intracellular H37Rv in infected THP-1 cells, control group means H37Rv-infected THP-1 macrophages without drug treatment