Scheme 1
CaCO3 nanoparticles loaded with Cur/QTX125 and coated with HA can effectively inhibit the growth of CRC cells. a Chemical structures of Cur, QTX125 and HA; b The preparation of CaCO3@Cur@QTX125@HA nanoparticles. NH4HCO3 was first decomposed into NH3 and CO2, which diffused into the CaCl2 solution containing Cur and QTX125. Then, CO2 reacted with Ca2+ to form Cur and QTX125 loaded CaCO3@Cur@QTX125 nanoparticles, which were subsequently coated with HA to generate CaCO3@Cur@QTX125@HA nanoparticles; c CaCO3@Cur@QTX125@HA nanoparticles can be taken up by CRC cells, Cur and QTX125 can be released to induce cell apoptosis