Fig. 3

PPI networks of M1-EV and M2-EV signature proteins. PPI analysis was conducted with the signature proteins of M1-EVs (A) and M2-EVs (B). The major protein clusters within each network were highlighted with different colors. The GO pathways that each protein cluster was enriched were indicated below the PPI networks. The clusters of enriched proteins in M1- or M2-EVs with (a) count in network > 5, (b) strength > 0.9, and (c) false discovery rate < 0.05 in GO terms were highlighted in the network. Count in network: the first number indicates number of proteins in the network that were annotated with a particular term, and the second number indicates number of proteins in total (in the network and in the background) that had this term assigned. Strength: describes the size of the enrichment effect; False discovery rate: describes the significance of the enrichment. FC: fold change