Fig. 6

Biomineralization-inspired crystallization of nanganese oxide on silk fibroin nanoparticles for in vivo MR/FL imaging-assisted tri-modal therapy of Cancer. A Schematic of SF@MnO2/ICG/DOX (SMID) nanoplatform for in vivo MR/FL imaging-assisted tri-modal therapy of cancer. B T1-weighted greyscale and pseudo-color MR images of 4T1 tumor-bearing mice (transverse plane sections) before and after intravenous injection of SMID nanoparticles (equivalent ICG concentration: 3 mg kg⁻¹). White dashed circles denote tumor locations. C Biodistribution of SMID nanoparticles in vivo: fluorescence images of 4T1 tumor-bearing mice taken at different time points after intravenous injection of ICG or SMID nanoparticles (equivalent ICG concentration: 3 mg kg⁻¹), and ex vivo fluorescence images and corresponding optical intensity of tumor and major organs (T, Li, Sp, Ki, H, and Lu denote tumor, liver, spleen, kidney, heart, and lung, respectively) dissected at 24 h post-injection. D Photographs of treated mice and the corresponding tumors excised at day 14 post-injection [276]