Fig. 3
Copyright 2019 Elsevier Ltd. B (i) the schematic of preparation of chitosan-bilirubin NPs and their mechanism of tumor treatment; (ii) the tumor volume and tumor weight in the HeLa tumor-bearing mouse model after treatment. Reproduced with permission. [90]. Copyright 2020 Elsevier Ltd. C Schematic of combination antitumor therapy with ROS-responsive nanogel prepared by in situ gelation of chitosan-thioketal-ferulic acid (CS-FT) conjugate, antiangiogenic Pazopanib (PAZ) and Laccase; (ii) A schematic representation of the synthesis, structure, and preparation of ROS. Reproduced with permission [92]. 2022 KeAi Communications Co. Ltd. D The assembly process and treatment mechanism of HA-coated PEI-ss-HECS-ss-OA NPs. Reproduced with permission. Reproduced with permission [84] Copyright 2020 American Chemical Society
A (i) schematic illustration of the hyaluronic acid (HA)/chitosan/SS31 NPs assembly process; (ii) the serum creatinine (Cr), blood urea nitrogen (BUN), and tissue apoptotic cell levels in the ischemia/reperfusion (I/R) injury-induced AKI rat model following different treatments. Reproduced with permission [88].