Fig. 6

Joint retention of RNPs. (A) Representative fluorescence images of knee joints from OA mice over 21 days after intra-articular injection of free DID (DID), DID-labeled MPs (DID-MPs) and DID-labeled NPs (DID-NPs), respectively. (B) Quantitative analysis of the time course of relative fluorescence intensity within knee joints after intra-articular injection of free DID (DID), DID-labeled MPs (DID-MPs) and DID-labeled NPs (DID-NPs), respectively. (C) Quantitative analysis of the area under the curve (AUC) based on the relative fluorescence intensity profile in (B). n = 5 per group. Statistical analysis was performed using one-way ANOVA with Tukey’s post hoc analysis. Data are presented as means ± SD. ns, non-significant. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001