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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Targeting and repolarizing M2-like tumor-associated macrophage-mediated MR imaging and tumor immunotherapy by biomimetic nanoparticles

Fig. 4

(A) Fluorescence images observed the expression of CD80 and CD206 in vitro after M2-like TAMs were treated with HMMDN(I), HMMDN@PM(II), Met(III), HMMDN-Met(IV), HMMDN-Met@MM(V), HMMDN-Met@PM(VI) (scale bar: 20 μm). (B) Quantitative analysis of CD80 fluorescence intensity on M2-like TAMs treated with different nanoparticles; (C) Quantitative analysis of CD206 fluorescence intensity on M2-like TAMs after different treatments (***P < 0.001). (D) Flow cytometric analysis of the expression of CD80 in vitro after M2-like TAMs were treated with different nanoparticles. (E) Flow cytometric analysis of the expression of CD206 in vitro after M2-like TAMs were treated with different nanoparticles. (F) The levels of immune cytokines, including TNF-α, iNOS, Arg-1 and IL-10 in M2-like TAMs supernatant after different treatments (**P < 0.01, ***P < 0.001)

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