Table 1 Physicochemical properties of functionalized and 5-FU loaded nanoparticles as well as respective controls, with mean size (Z-average size), polydispersity index, surface charge (ζ-Potential), and DL (%). Values are represented as mean values ± SD (N = 6). Non applicable (−)
Size (nm) | Polydispersity index | Surface charge (Mv) | Drug loading (%) | |
|---|---|---|---|---|
Empty PLGA NPs | 164.6 ± 5.1 | 0.21 ± 0.01 | − 7.46 ± 0.30 | |
5-FU loaded PLGA NPs | 169.9 ± 2.9 | 0.19 ± 0.01 | − 6.62 ± 0.38 | 4.7 ± 2.3 |
Empty NF NPs | 142.4 ± 6.8 | 0.25 ± 0.03 | − 5.55 ± 0.81 | |
Empty N NPs | 136.8 ± 2.1 | 0.22 ± 0.01 | − 9.22 ± 0.84 | |
5-FU loaded F NPs | 133.7 ± 1.3 | 0.25 ± 0.01 | 12.53 ± 0.37 | 8.3 ± 3.9 |