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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Bone-targeting exosome nanoparticles activate Keap1 / Nrf2 / GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells

Fig. 4

RNA-Seq showed that BT-EXO-CAP promoted ferroptosis in 143B cells. (A) Visualization of differentially expressed genes (DEGs) in cells treated with PBS, BT-EXO, and BT-EXO-CAP using a heatmap. n = 3. (B-C) Venn diagram of total DEGs and overexpressed genes. (D) RNA expression of ferroptosis-related genes. (E) Analysis of altered genes in top categories relying on KEGG from BT-EXO vs. BT-EXO-CAP (fold change ≥ ± 2 & P -value < 0.05)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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