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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Bone-targeting exosome nanoparticles activate Keap1 / Nrf2 / GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells

Fig. 5

BT-EXO-CAP induced ferroptosis in human OS cells. (A) Representative TEM picture of mitochondria. (B) Flow cytometry-based detection of FerroOrange fluorescence in OS cells. (C) DCFH-DA fluorescence of OS cells captured by fluorescence microscope. (D) Flow cytometry-based detection of C11-BODIPY fluorescence in OS cells. (E) Measurement of ferroptosis-related protein expressions via WB. (F) GSH levels in OS cells. n = 6. (G) Cell viability of OS cells. n = 10. (H) Flow cytometry-based detection of FerroOrange and (I) C11-BODIPY fluorescence in OS cells. (J) GSH levels in OS cells. n = 6. * p < 0.05, ** p < 0.01, *** p < 0.001. Scale bar: A 1 μm, C 100 μm

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Journal of Nanobiotechnology

ISSN: 1477-3155

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