Fig. 5

RNA sequencing of 7CZ nanomedicines application in ADR-treated podocytes. a PCA was performed based on differentially expressed genes with or without 7CZ nanomedicines. Each data point corresponds to the PCA analysis of each sample. b Heatmap of significant genes involved after 7CZ nanomedicines treatment (fold change ≥ 2 and P < 0.05). c Volcano plots showing the identified upregulated and downregulated genes by 7CZ nanomedicines. d GO analysis of the DEGs in NS after 7CZ nanomedicines treatment. e KEGG pathway enrichment analysis of the identified differentially expressed genes. f KEGG pathway enrichment analysis of differentially expressed genes associated with ROS. The 5 most significantly enriched pathways are shown in g and h