Fig. 9

Haematoxylain and eosin rats’ skin section showing A] normal skin layers consist of epidermis (red arrow) and dermis (blue arrow) in unwounded NC GI on the 1st, 7th or14th day PT(H&E X100), B] and C] necrosis (red arrow) associated with congested dermal blood vessels (blue arrow), inflammatory cells infiltration (yellow arrow) and hemorrhage (H&E X100) in all wounded groups (GII to GVIII) on the 1st day PT, D] scab formation (red arrow), edema associated with inflammatory infiltration (yellow arrow) and poorly developed granulation tissue (green arrow) in PC GII on the 7th day PT(H&E X100), E] congested newly formed blood capillaries (angiogenesis) (blue arrow) in PC GII on the 7th day PT(H&E X100), F] and G] focal necrosis (red arrow), poorly developed granulation tissue (green arrow) and inflammatory cells infiltration (yellow arrow) in SE (25 and 50 mg/kg) GIII and GIV on the 7th day PT (H&E x100), H] and I] scab formation (red arrow), inflammatory edema with poorly developed granulation tissue (green arrow) in CS NPs (25 and 50 mg/kg) GV and GVI on the 7th day PT (H&E X100), J] and K] inflammatory edema (blue arrow) and poorly developed granulation tissue (green arrow) in SE-CS NPs (25 and 50 mg/kg) GVII and GVIII on the 7th day PT (H&E X100), L] necrosis (red arrow) and marked inflammatory infiltration (blue arrow) in PC GII on the 14th day PT (H&E X100), M] and N] inflammatory edema (blue arrow) and granulation tissue formation (yellow arrow) in SE (25 and 50 mg/kg) GIII and GIV on the 14th day PT (H&E X100), O] and P] inflammatory edema with areas of hemorrhage and necrosis (red arrow) and poorly developed granulation tissue in CS NPs (25 and 50 mg/kg) GV and GVI on the 14th day PT (H&E X100), Q] and R] re-epithelization, formation of epidermal layer (red arrow), well oriented granulation tissue and well developed collagen fibers (blue arrow)in SE-CS NPs (25 and 50 mg/kg) GVII and GVIII on the 14th day PT (H&E X100)