Fig. 9

Comprehensive assessments of the wound microenvironment after treatment with PB@Algs-H hydrogels using RNA sequencing. (A) PCA based on DEGs in the wound tissue between the control and PB@Algs-H groups. (B) Heat map of upregulated and downregulated genes in the deep second-degree burn wound microenvironment after treatment with PB@Algs-H hydrogels (fold change ≥ 4 and P < 0.05). (C) Volcano plots showing the upregulated and downregulated genes in response to PB@Algs-H hydrogels treatment. (D) GO enrichment analysis of the upregulated genes. (E) GO enrichment analysis of the downregulated genes