Table 1 LNPs for the delivery of siRNA
From: Engineering siRNA therapeutics: challenges and strategies
LNPs | Shape | Type of study | Aid | Ref. |
|---|---|---|---|---|
DOPE, DOTMA, DPPE-PEG 2000 | Spherical | In-vivo | Receptor-mediated targeted delivery | [108] |
Toc-siRNA | Spherical | In-vivo | Improved stability and cleaving efficiency of siRNA, targeted delivery, no side effects | [109] |
DLinDAP, DLinDMA, DLinKDMA, or DLinKC2-DMA | Spherical | In-vitro | Â | [110] |
AtuFECT01 | Spherical | In-vivo and In-vitro | Targeted delivery, stable in bloodstream | [111] |