Table 2 Polymer NPs for the delivery of siRNA
From: Engineering siRNA therapeutics: challenges and strategies
Polymeric NPs | Study | Cell lines | Aid | Ref. |
|---|---|---|---|---|
PEI-HYD | In vivo and in vitro | HUVECs | Targeted delivery | [151] |
PLGA | In vitro | H1299 | Improved encapsulation efficiency, high stability, highly resistant to nuclease degradation | [152] |
PLGA-PLL-PEG | In vitro | HEK293T and A549 | Site-specific delivery, improved endosomal escape and controlled release | [153] |
Chitosan | In vivo and in vitro | H1299; NIH 3T3; mouse lung | Enhanced transfection efficiency, protection from nuclease degradation, low cytotoxicity | [154] |
Chitosan-mPEG | In vivo | Mouse xenograft | Improved cell permeability and blood retention time | [155] |