Fig. 4
From: Enhanced antidepressant effects of BDNF-quercetin alginate nanogels for depression therapy
Distribution in brain and pharmacokinetic study of quercetin nanogels. (a) Fluorescence analysis of quercetin nanogels in the brain. (b) Hippocampal quercetin concentration-time curves after intragastric or intranasal delivery. Pharmacokinetic parameters include (c) Tmax (h), (d) Cmax (ng/g), (e) AUC0 − tn (ng/g·h), (f) AUC0−∞ (ng/g·h), (g) MRT0−∞(h), (h), MRT0 − tn(h). **p < 0.01 compared with the orally administrated quercetin solution