Fig. 9
From: Enhanced antidepressant effects of BDNF-quercetin alginate nanogels for depression therapy
Antidepressant mechanism of BDNF-Quercetin nanogels in the thermosensitive gel on the CUMS rats. (a) Volcano map. (b) GO enrichment analysis. (c) KEGG pathway enrichment analysis of BDNF-quercetin nanogels vs. CUMS model. (d) Partial least squares-discriminant analysis (PLS-DA). (e) VIP analysis. (f) Major metabolic pathways that BDNF-Quercetin nanogels improve CUMS rats. (g-h) Expression of GRIA3, BDNF, TrkB, P-mTOR, GRIN2B, and GSK3β in the hippocampus of rats. ##p < 0.01 compared with the control group. **p < 0.01 compared with the CUMS group